Protein kinase C inhibition in the treatment of mania

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Yildiz A., Guleryuz S., Ankerst D. P., Ongur D., Renshaw P. F.

ARCHIVES OF GENERAL PSYCHIATRY, vol.65, no.3, pp.255-263, 2008 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 65 Issue: 3
• Publication Date: 2008
• Doi Number: 10.1001/archgenpsychiatry.2007.43
• Journal Name: ARCHIVES OF GENERAL PSYCHIATRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
• Page Numbers: pp.255-263
• Open Archive Collection: AVESIS Open Access Collection
• Dokuz Eylül University Affiliated: Yes

Abstract

Context: Findings that protein kinase C ( PKC) activity may be altered in mania, and that both lithium carbonate and valproate sodium inhibit PKC-associated signaling in brain tissue, encourage development of PKC inhibitors as candidate antimanic agents.