Protein kinase C inhibition in the treatment of mania


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Yildiz A., Guleryuz S., Ankerst D. P., Ongur D., Renshaw P. F.

ARCHIVES OF GENERAL PSYCHIATRY, cilt.65, sa.3, ss.255-263, 2008 (SCI-Expanded) identifier identifier identifier

Özet

Context: Findings that protein kinase C ( PKC) activity may be altered in mania, and that both lithium carbonate and valproate sodium inhibit PKC-associated signaling in brain tissue, encourage development of PKC inhibitors as candidate antimanic agents.