The Effect of Rapid Antigen Detection Test on Antibiotic Prescription Decision of Clinicians and Reducing Antibiotic Costs in Children with Acute Pharyngitis

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Kose E., Kose Ş., Akca D., Yildiz K., Elmas C., Baris M., ...More

JOURNAL OF TROPICAL PEDIATRICS, vol.62, no.4, pp.308-315, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1093/tropej/fmw014
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.308-315
  • Keywords: pharyngitis, rapid antigen detection test, throat culture, Group A streptococcus, Centor score, antibiotic costs, STREPTOCOCCAL PHARYNGITIS, CULTURE CONFIRMATION, DIAGNOSIS, SENSITIVITY, MANAGEMENT, PRINCIPLES, GUIDELINES, SYMPTOMS, THERAPY, THROAT
  • Dokuz Eylül University Affiliated: Yes


We aimed to investigate the effect of rapid antigen detection test (RADT) in the diagnosis of streptococcal pharyngitis, its impact on antibiotic prescription decision of pediatricians and influence on reduction of antibiotic treatment costs in children with pharyngitis. The study group consisted of 223 patients who were diagnosed with pharyngitis by pediatricians. The sensitivity and specificity of RADT were 92.1% (95% Cl: 78.6-98.3%) and 97.3% (95% Cl: 93.8-99.1%), respectively. In the first assessment, before performing RADT, pediatricians decided to prescribe antibiotics for 178 (79.8%) patients with pharyngitis. After learning RADT results, pediatricians finally decided to prescribe antibiotics for 83 (37.2%) patients with pharyngitis, and antibiotic prescription decreased by 42.6%. Antibiotic costs in non-Group A streptococcus pharyngitis, Group A streptococcus pharyngitis and all subjects groups decreased by 80.8%, 48%, and 76.4%, respectively. Performing RADT in children with pharyngitis has an important impact on treatment decision of clinicians, reduction of unnecessary antibiotic prescriptions and antibiotic costs.