Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum

Gungor T., Acar S., Kahraman E., Bozkurt O., Durmuş Sütpideler N.

JOURNAL OF UROLOGICAL SURGERY, cilt.7, sa.3, ss.204-210, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/jus.galenos.2020.3363
  • Dergi Adı: JOURNAL OF UROLOGICAL SURGERY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.204-210
  • Anahtar Kelimeler: Resveratrol, Resistin, Erectile dysfunction, Corpus cavernosum, Rabbit, VASCULAR SMOOTH-MUSCLE, ERECTILE DYSFUNCTION, TYPE-1, RISK
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Resistin is an important factor in the pathogenesis of obesity-induced insulin resistance and endothelial dysfunction-mediated cardiovascular system diseases. Endothelial dysfunction is one of the most important causes of erectile dysfunction. Polyphenol resveratrol has several pharmacological functions, such as preventing endothelial dysfunction and inducing endothelium-dependent vascular relaxation via redox regulation and nitric oxide production. The present study tested the hypothesis that resveratrol restores endothelium-mediated responses that are disrupted by resistin.