Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum

Gungor T., Acar S., Kahraman E., Bozkurt O., Durmuş Sütpideler N.

JOURNAL OF UROLOGICAL SURGERY, vol.7, no.3, pp.204-210, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.4274/jus.galenos.2020.3363
  • Journal Name: JOURNAL OF UROLOGICAL SURGERY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.204-210
  • Keywords: Resveratrol, Resistin, Erectile dysfunction, Corpus cavernosum, Rabbit, VASCULAR SMOOTH-MUSCLE, ERECTILE DYSFUNCTION, TYPE-1, RISK
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Resistin is an important factor in the pathogenesis of obesity-induced insulin resistance and endothelial dysfunction-mediated cardiovascular system diseases. Endothelial dysfunction is one of the most important causes of erectile dysfunction. Polyphenol resveratrol has several pharmacological functions, such as preventing endothelial dysfunction and inducing endothelium-dependent vascular relaxation via redox regulation and nitric oxide production. The present study tested the hypothesis that resveratrol restores endothelium-mediated responses that are disrupted by resistin.