Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.27, no.5, pp.1491-1496, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 27 Issue: 5
- Publication Date: 2014
- Journal Name: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1491-1496
- Keywords: Oleanolic acid, amino acid, HCC cell lines, amides, Periploca aphylla, URSOLIC ACID, BETULINIC ACID, TRITERPENOIDS, CANCER, DERIVATIVES, PREVENTION, APOPTOSIS, OLEANANE
- Dokuz Eylül University Affiliated: Yes
Abstract
Oleanolic acid (3 beta-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological ad biological activities. We have isolated oleanolic acid from methanolic extract of Perzploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased /higher inhibition rates.