Neurotoxicity Associated With Dimethyl Sulfoxide Used in Allogeneic Stem Cell Transplantation

Ataseven E., TÜFEKÇİ Ö., YILMAZ Ş., GÜLERYÜZ UÇAR H., ÖREN H.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.39, sa.5, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1097/mph.0000000000000784
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: dimethyl sulfoxide, stem cell transplantation, seizures, toxicity, PROGENITOR CELLS, INFUSION, TOXICITY, BLOOD, DMSO, 5-PERCENT
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Dimethyl sulfoxide (DMSO) is a cryoprotective agent used in storage of frozen stem cells in stem cell transplantation. Central nervous system side effects of DMSO such as epileptic seizures, stroke, transient global amnesia, and temporary leucoencephalopathy are rarely seen. Here, we report a pediatric patient who developed seizures after DMSO-cryopreserved stem cell infusion and whose magnetic resonance imaging of the brain demonstrated parietal and occipital focal cortical T2-signal intensity increase. DMSO toxicity should be kept in mind in patients who received cryopreserved stem cell infusion and magnetic resonance imaging may be helpful in differential diagnosis of central nervous system involvement.