Neurotoxicity Associated With Dimethyl Sulfoxide Used in Allogeneic Stem Cell Transplantation


Ataseven E., TÜFEKÇİ Ö., YILMAZ Ş., GÜLERYÜZ UÇAR H., ÖREN H.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.39, no.5, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1097/mph.0000000000000784
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: dimethyl sulfoxide, stem cell transplantation, seizures, toxicity, PROGENITOR CELLS, INFUSION, TOXICITY, BLOOD, DMSO, 5-PERCENT
  • Dokuz Eylül University Affiliated: Yes

Abstract

Dimethyl sulfoxide (DMSO) is a cryoprotective agent used in storage of frozen stem cells in stem cell transplantation. Central nervous system side effects of DMSO such as epileptic seizures, stroke, transient global amnesia, and temporary leucoencephalopathy are rarely seen. Here, we report a pediatric patient who developed seizures after DMSO-cryopreserved stem cell infusion and whose magnetic resonance imaging of the brain demonstrated parietal and occipital focal cortical T2-signal intensity increase. DMSO toxicity should be kept in mind in patients who received cryopreserved stem cell infusion and magnetic resonance imaging may be helpful in differential diagnosis of central nervous system involvement.