Positive effects of ketogenic diet on weight control in children with obesity due to Prader-Willi syndrome

---

Atıf İçin Kopyala

Teke Kısa P., Güzel O., ARSLAN N., DEMİR K.

CLINICAL ENDOCRINOLOGY, sa.3, ss.332-341, 2023 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Basım Tarihi: 2023
• Doi Numarası: 10.1111/cen.14864
• Dergi Adı: CLINICAL ENDOCRINOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, CAB Abstracts, EMBASE, Gender Studies Database
• Sayfa Sayıları: ss.332-341
• Anahtar Kelimeler: appetite, dietary intake, hyperphagia, ketones, obesity, weight loss
• Dokuz Eylül Üniversitesi Adresli: Evet

Özet

ObjectivePrader-Willi Syndrome (PWS) is the most common genetic cause of obesity. Prevention and management of obesity, which represents the main cause of morbidity and mortality in these patients, is essential. Ketogenic diet (KD) is used in the treatment of various disorders, however knowledge of its effect in PWS is lacking. The present study assesses the characteristics of patients with PWS who were on KD. Design and PatientsThis is a retrospective, cross-sectional descriptive study investigating the subjects with PWS, who had received KD for at least 6 months. ResultsTen patients with PWS [median age 52.5 (47-77) months] complied with KD. The median treatment period was 16.5 [11-52] months. Of the daily calorie, 75%-85% were from fat, and 15%-25% from protein + carbohydrate. The baseline body weight standard deviation (SD) score before diet therapy was 2.10 [-1.11-4.11], whereas it was 0.05 [-0.92-1.2] at final evaluation (p = .007). The baseline median BMI SD score before diet therapy was 3.05 [-0.21-3.72], whereas it was 0.41 [-0.87-1.57] at final evaluation (p = .002). The height SD score remained unchanged. Mild hypercholesterolaemia was the most common biochemical abnormality during treatment with KD. ConclusionOur results indicate that KD might have a favourable effect on weight management in PWS.