Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage
EXPERT OPINION ON DRUG DELIVERY, vol.13, no.12, pp.1695-1708, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 13 Issue: 12
- Publication Date: 2016
- Doi Number: 10.1080/17425247.2016.1200556
- Journal Name: EXPERT OPINION ON DRUG DELIVERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1695-1708
- Keywords: Alpha-lipoic acid, antioxidant activity, drug delivery, gynecology, immunomodulation, inflammation, miscarriage, NF-kappa B, Nrf2, subchorionic hematoma, vaginal route
- Dokuz Eylül University Affiliated: Yes
Abstract
Introduction: Alpha lipoic acid (ALA) is an essential mitochondrial co-factor and, as a free molecule, it can exert multi-level immunomodulatory functions. Both ALA and its reduced form, dihydrolipoic acid (DHLA), are believed to be able to chelate heavy metals, to regenerate essential antioxidants and to repair important molecules damaged by oxidation. The largest part of the effects of ALA/DHLA couple can be explained by a specific stimulatory activity on Nrf2-dependent gene transcription and by the inhibition of NF-kappa B activity. These features have prompted its use as a drug for several diseases.