Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage

Monastra G., De Grazia S., CİLAKER MIÇILI S., GÖKER A., Unfer V.

EXPERT OPINION ON DRUG DELIVERY, cilt.13, sa.12, ss.1695-1708, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13 Sayı: 12
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1080/17425247.2016.1200556
  • Dergi Adı: EXPERT OPINION ON DRUG DELIVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1695-1708
  • Anahtar Kelimeler: Alpha-lipoic acid, antioxidant activity, drug delivery, gynecology, immunomodulation, inflammation, miscarriage, NF-kappa B, Nrf2, subchorionic hematoma, vaginal route, NF-KAPPA-B, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, HUMAN FETAL MEMBRANES, SYMPTOMATIC DIABETIC POLYNEUROPATHY, RECURRENT SPONTANEOUS-ABORTION, PERIPHERAL-BLOOD LYMPHOCYTES, CONTROLLED-TRIAL ALADIN, T-CELL MIGRATION, OXIDATIVE STRESS, SIGNALING PATHWAY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction: Alpha lipoic acid (ALA) is an essential mitochondrial co-factor and, as a free molecule, it can exert multi-level immunomodulatory functions. Both ALA and its reduced form, dihydrolipoic acid (DHLA), are believed to be able to chelate heavy metals, to regenerate essential antioxidants and to repair important molecules damaged by oxidation. The largest part of the effects of ALA/DHLA couple can be explained by a specific stimulatory activity on Nrf2-dependent gene transcription and by the inhibition of NF-kappa B activity. These features have prompted its use as a drug for several diseases.