An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

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Direk N., Williams S., Smith J. A., Ripke S., Air T., Amare A. T., ...More

BIOLOGICAL PSYCHIATRY, vol.82, no.5, pp.322-329, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1016/j.biopsych.2016.11.013
  • Journal Name: BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.322-329
  • Keywords: CHARGE consortium, Depressive symptoms, FHIT gene, Genome-wide association study, Major depressive disorder, Psychiatric Genomics Consortium, MINOR DEPRESSION, MAJOR DEPRESSION, SUBTHRESHOLD DEPRESSION, SYMPTOMS, RISK, DISORDER, STRESS, HERITABILITY, PREVALENCE, DISABILITY
  • Dokuz Eylül University Affiliated: No

Abstract

BACKGROUND: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder.