An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

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Direk N., Williams S., Smith J. A., Ripke S., Air T., Amare A. T., ...Daha Fazla

BIOLOGICAL PSYCHIATRY, cilt.82, sa.5, ss.322-329, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.biopsych.2016.11.013
  • Dergi Adı: BIOLOGICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.322-329
  • Anahtar Kelimeler: CHARGE consortium, Depressive symptoms, FHIT gene, Genome-wide association study, Major depressive disorder, Psychiatric Genomics Consortium, MINOR DEPRESSION, MAJOR DEPRESSION, SUBTHRESHOLD DEPRESSION, SYMPTOMS, RISK, DISORDER, STRESS, HERITABILITY, PREVALENCE, DISABILITY
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

BACKGROUND: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder.