The outcomes of favipiravir exposure in pregnancy: a case series.

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Ertem O., Guner O., Incir C., Kalkan S., Gelal A.

Archives of gynecology and obstetrics, cilt.307, sa.1, ss.1385-1395, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 307 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00404-022-06615-z
  • Dergi Adı: Archives of gynecology and obstetrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1385-1395
  • Anahtar Kelimeler: Favipiravir, Pregnancy outcomes, Teratogen
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose As in vitro and in vivo studies reported antiviral efficacy against RNA viruses, favipiravir, a pyrazinecarboxamide derivative, has become one of the treatment options for COVID-19 in some countries including Turkey. Preclinical studies demonstrated the risk for teratogenicity and embryotoxicity. Hence, the drug is contraindicated during pregnancy. Although limited in numbers, case-based evaluations indicate that favipiravir might not be a major teratogen in human pregnancies. This study aimed to present and analyze the outcomes of favipiravir exposure during pregnancy.