Electropolymerized poly(Congo red) on graphene oxide: a novel platform for electrochemical sensing of acyclovir


KOÇAK Ç. C., Karabiberoğlu Ş.

Analytical Methods, cilt.17, sa.36, ss.7156-7166, 2025 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 36
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1039/d5ay00921a
  • Dergi Adı: Analytical Methods
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, CAB Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.7156-7166
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

In this work, a composite electrode was prepared by the electropolymerization of Congo red on a graphene oxide glassy carbon electrode (PCR/GO/GCE). The modified electrode surface was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The electrochemical behavior of acyclovir (ACV), a widely used antiviral drug, was investigated using CV and DPV techniques in pH 5.1 Britton-Robinson (BR) buffer. Selective and stable responses were exhibited by the developed electrode, which provided a 45-fold higher current value compared to the bare GCE. DPV studies revealed linear ranges between 0.01 μmol L−1 and 1.3 μmol L−1 and between 2.2 and 18 μmol L−1, with a detection limit of 3.4 nmol L−1. The practical applicability of PCR/GO/GCE was demonstrated in pharmaceutical real sample analysis with high accuracy.