Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.25, sa.5, ss.202-206, 1997 (Scopus)
Twelve New Zealand Rabbits were studied to evaluate the effects of MgSO4 on cerebral ischemia. The subjects were tracheostomised under propofol anaesthesia and mechanically ventilated. Haemorrhagic hypotensive ischemia was achieved for a duration of one hour. Blood samples were obtained at 30 minute intervals during the study for arterial blood gas analysis and haematocrit determinations. At the end of ischemia the subjects were randomly allocated into two groups. First group received magnesium sulphate infusion at a rate of 2.5 mmol/kg/hr while the second group received 0.9% NaCl infusion of 1 mL/kg/hr during the reperfusion period. Rabbits were decapitated and their brains were taken for histological examination following reperfusion. Corononry sections of brain tissue were incubated in nitro blue tetrosolium and left in 10% formoline for one week. After staining with hematoxylene-eosine they were evaluated by a pathologist under light microscope with a 10 point ischemic scale. The pathologist was not informed about the study. Acute period ischemic area and cerebral cortical cell damage was found to be increased with magnesium sulphate infusion. It was concluded that 2.5 mmol/kg/hr magnesium sulphate does not prevent ischemic injury in the rabbits under propofol anaesthesia and further investigations are required.