Repositioning of Metformin: Anticancer Agent for Hypoxic Neuroblastoma Cells
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.4, sa.3, ss.384-390, 2020 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.30621/jbachs.2020.1373
- Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.384-390
- Anahtar Kelimeler: neuroblastoma, metformin, hypoxia, HIF-1 alpha, VEGF-A, PDK-1
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Objectives:Neuroblastoma is an extracranial solid tumor of early childhood that has a hypoxic environment. VEGF and HIFs molecules play a role in adaptation to this microenvironment. Hypoxic microenvironment leads to poor prognosis and inadequate treatment of neuroblastoma. Metformin has been shown to inhibit tumor growth, might be a potential chemotherapeutic agent. The anti-cancer activity of Metformin on SH-SY5Y cells are not fully elucidated. The aim of this study is to determine the anti-cancer effect of Metformin on SH-SY5Y cells and to elucidate its molecular action mechanism in hypoxia/normoxia.