Expression of Bcl-2, Bax and p53 proteins in pituitary adenomas: an immunohistochemical study.

Ozer E., Canda M., Ulukus C., Guray M., Erbayraktar S.

Tumori, cilt.89, sa.1, ss.54-9, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1177/030089160308900112
  • Dergi Adı: Tumori
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.54-9
  • Anahtar Kelimeler: Bax, Bcl-2, p53, pituitary adenoma, APOPTOSIS, MANAGEMENT, TUMORS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Aims and background: Although pituitary adenomas are usually benign lesions, their growth rate is highly variable and unpredictable. Apoptosis appears to be an important process in neoplastic lesions. The purpose of this study was to investigate the expression of apoptosis-related proteins including Bcl-2, bax and p53 in pituitary adenomas and its correlation with hormone function, tumor size, local control, and proliferative activity.