Expression of Bcl-2, Bax and p53 proteins in pituitary adenomas: an immunohistochemical study.

Ozer E., Canda M., Ulukus C., Guray M., Erbayraktar S.

Tumori, vol.89, no.1, pp.54-9, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1177/030089160308900112
  • Journal Name: Tumori
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.54-9
  • Keywords: Bax, Bcl-2, p53, pituitary adenoma, APOPTOSIS, MANAGEMENT, TUMORS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aims and background: Although pituitary adenomas are usually benign lesions, their growth rate is highly variable and unpredictable. Apoptosis appears to be an important process in neoplastic lesions. The purpose of this study was to investigate the expression of apoptosis-related proteins including Bcl-2, bax and p53 in pituitary adenomas and its correlation with hormone function, tumor size, local control, and proliferative activity.