Effects of long-term methylphenidate treatment: A pilot follow-up clinical and SPECT study


AKAY A., ÇAPA KAYA G., Emiroglu N. I., Aydin A., Monkul E. S., Tasci C., ...More

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol.30, no.7, pp.1219-1224, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 30 Issue: 7
  • Publication Date: 2006
  • Doi Number: 10.1016/j.pnpbp.2006.02.014
  • Journal Name: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1219-1224
  • Keywords: attention deficit hyperactivity disorder, methylphenidate, pre- and post-treatment, SPECT, DEFICIT HYPERACTIVITY DISORDER, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, CEREBRAL-BLOOD-FLOW, COMPUTED-TOMOGRAPHY SPECT, GLUCOSE-METABOLISM, CHILDREN, ADHD, ABNORMALITIES, ADULTS, ADOLESCENTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Although abnormalities in the regional cerebral blood flow (rCBF) responses to methylphenidate (MPH) treatment have been reported in children with attention deficit hyperactivity disorder (ADHD), there are few prospective longitudinal studies assessing the long-term effects of MPH and discontinuation effects after chronic treatment.