Systematic Analysis of Cytostatic TGF-Beta Response in Mesenchymal-Like Hepatocellular Carcinoma Cell Lines

Gungor M. Z., Uysal M., Ozturk M., Şentürk Ş.

JOURNAL OF GASTROINTESTINAL CANCER, vol.52, no.4, pp.1320-1335, 2021 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1007/s12029-021-00704-z
  • Journal Name: JOURNAL OF GASTROINTESTINAL CANCER
  • Page Numbers: pp.1320-1335
  • Keywords: Hepatocellular carcinoma, TGF-beta pathway, Cytostatic response, HCC cell lines, Mesenchymal, TRANSFORMING-GROWTH-FACTOR, HEPATOMA-CELLS, CANCER, EXPRESSION, RECEPTOR, HEPATOCYTES, INHIBITION, TRANSITION, MUTATIONS, PATHWAYS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background Hepatocellular carcinoma (HCC) is one of the most challenging malignancies, with high morbidity and mortality rates. The transforming growth factor-beta (TGF-beta) pathway plays a dual role in HCC, acting as both tumor suppressor and promoter. A thorough understanding of the mechanisms underlying its opposing functions is important. The growth suppressive effects of TGF-beta remain largely unknown for mesenchymal HCC cells. Using a systematic approach, here we assess the cytostatic TGF-beta responses and intracellular transduction of the canonical TGF-beta/Smad signaling cascade in mesenchymal-like HCC cell lines.