Systematic Analysis of Cytostatic TGF-Beta Response in Mesenchymal-Like Hepatocellular Carcinoma Cell Lines
JOURNAL OF GASTROINTESTINAL CANCER, vol.52, no.4, pp.1320-1335, 2021 (Scopus)
- Publication Type: Article / Article
- Volume: 52 Issue: 4
- Publication Date: 2021
- Doi Number: 10.1007/s12029-021-00704-z
- Journal Name: JOURNAL OF GASTROINTESTINAL CANCER
- Journal Indexes: Scopus
- Page Numbers: pp.1320-1335
- Keywords: Hepatocellular carcinoma, TGF-beta pathway, Cytostatic response, HCC cell lines, Mesenchymal
- Dokuz Eylül University Affiliated: Yes
Abstract
Background Hepatocellular carcinoma (HCC) is one of the most challenging malignancies, with high morbidity and mortality rates. The transforming growth factor-beta (TGF-beta) pathway plays a dual role in HCC, acting as both tumor suppressor and promoter. A thorough understanding of the mechanisms underlying its opposing functions is important. The growth suppressive effects of TGF-beta remain largely unknown for mesenchymal HCC cells. Using a systematic approach, here we assess the cytostatic TGF-beta responses and intracellular transduction of the canonical TGF-beta/Smad signaling cascade in mesenchymal-like HCC cell lines.