Diurnal Differences in Toluene Induced Reward-Seeking Behavior Between Melatonin-Proficient (C3H) and Melatonin-Deficient (C57) Mice

Akhisaroglu M., AKSU İ., Topcu A., Semin I.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.30, no.2, pp.240-248, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2013
  • Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.240-248
  • Keywords: Toluene, Reward Seeking, Conditioning Place Preferences, Diurnal, Melatonin, Mice, CONDITIONED PLACE PREFERENCE, PINEAL-GLAND, COCAINE SENSITIZATION, N-ACETYLTRANSFERASE, ORGANIC-SOLVENTS, RAT, EXPRESSION, EXPOSURE, RHYTHM, GENES
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: Abuse of organic volatile substances (inhalants) has become a social health problem that is increasing in the recent years. Toluene as a prototype of inhalants can be use via inhalation, intraperitoneal or intravenous for experimental research on rodents. A conditioning paradigm of toluene inhalation was developed the rewarding effect in mice and rats. Aim of this research, investigation of toluene induced reward-seeking behavior at day and night order in melatonin proficient (C3H) and deficient (C57) mice.