Genetic imaging study with [Tc-(99m)] TRODAT-1 SPECT in adolescents with ADHD using OROS-methylphenidate

AKAY, AYNUR; ÇAPA KAYA, GAMZE; Kose, Samet; ERESEN YAZICIOĞLU, ÇİĞDEM; Erkuran, Handan; ALŞEN GÜNEY, SEVAY; Oguz, Kaya; Keskin, Duygu; BAYKARA, HÜSEYİN; Emiroglu, Neslihan; Eren, Mine; KIZILDAĞ, SEFA; ERTAY, TÜRKAN; Ozsoylu, Dua; Miral, Suha; Durak, Hatice; Gonul, Ali; Rohde, Luis

doi:10.1016/j.pnpbp.2018.04.008

Genetic imaging study with [Tc-(99m)] TRODAT-1 SPECT in adolescents with ADHD using OROS-methylphenidate

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AKAY A., ÇAPA KAYA G., Kose S., ERESEN YAZICIOĞLU Ç., Erkuran H. O., ALŞEN GÜNEY S., ...More

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol.86, pp.294-300, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 86
Publication Date: 2018
Doi Number: 10.1016/j.pnpbp.2018.04.008
Journal Name: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.294-300
Keywords: ADHD, DAT1 gene, [Tc-(99m)] TRODAT-1 SPECT, OROS-methylphenidate, DEFICIT HYPERACTIVITY DISORDER, DOPAMINE-TRANSPORTER GENE, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, TC-99M-TRODAT-1 SPECT, PARKINSONS-DISEASE, CHILDREN, ASSOCIATION, ADULTS, PSYCHOSTIMULANTS, AVAILABILITY
Dokuz Eylül University Affiliated: Yes

Abstract

Aim: To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-(99m)] TRODAT-1SPECT in a sample of treatment-naive adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability.