Genetic imaging study with [Tc-(99m)] TRODAT-1 SPECT in adolescents with ADHD using OROS-methylphenidate

AKAY, AYNUR; ÇAPA KAYA, GAMZE; Kose, Samet; ERESEN YAZICIOĞLU, ÇİĞDEM; Erkuran, Handan; ALŞEN GÜNEY, SEVAY; Oguz, Kaya; Keskin, Duygu; BAYKARA, HÜSEYİN; Emiroglu, Neslihan; Eren, Mine; KIZILDAĞ, SEFA; ERTAY, TÜRKAN; Ozsoylu, Dua; Miral, Suha; Durak, Hatice; Gonul, Ali; Rohde, Luis

doi:10.1016/j.pnpbp.2018.04.008

Genetic imaging study with [Tc-(99m)] TRODAT-1 SPECT in adolescents with ADHD using OROS-methylphenidate

AKAY A., ÇAPA KAYA G., Kose S., ERESEN YAZICIOĞLU Ç., Erkuran H. O., ALŞEN GÜNEY S., ...Daha Fazla

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, cilt.86, ss.294-300, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 86
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.pnpbp.2018.04.008
Dergi Adı: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.294-300
Anahtar Kelimeler: ADHD, DAT1 gene, [Tc-(99m)] TRODAT-1 SPECT, OROS-methylphenidate
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Aim: To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-(99m)] TRODAT-1SPECT in a sample of treatment-naive adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability.