Nicotine lowers TNF-alpha, IL-1b secretion and leukocyte accumulation via nAChR in rat stomach

KIZILDAĞ S., Hosgorler F. U., Guvendi G., KOÇ T. B., KANDİŞ S., Argon A., ...Daha Fazla

TOXIN REVIEWS, cilt.40, sa.1, ss.17-24, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/15569543.2020.1790604
  • Dergi Adı: TOXIN REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, BIOSIS, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.17-24
  • Anahtar Kelimeler: Nicotine, TNF, IL-10, inflammation, stomach, INDUCED GASTRIC INJURY, ACETYLCHOLINE-RECEPTORS, UP-REGULATION, KAPPA-B, SMOKING, INFLAMMATION, ACTIVATION, MEDIATORS, ADHESION, COLITIS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Inflammatory suppressive effects of nicotine have been observed in inflammatory diseases. We aimed to investigate morphological damage and the changes in TNF-alpha, IL-1 beta, and IL-10 expression in the healthy stomach after long-term oral nicotine administration. Nicotine was added to the drinking water of Sprague Dawley rats for 6 weeks. Histological signs of damage, inflammatory cytokines, and nicotinic acetylcholine receptor (nAChR) levels were evaluated in the gastric tissues. There were no histological signs of inflammation in both groups. TNF-alpha and IL-1 beta were decreased in the nicotine-treated group. A positive correlation was found between TNF-alpha levels and infiltrated inflammatory cell count. nAChR levels were increased in the nicotine group. Long term nicotine administration upregulates and activates nAChR. The reduced TNF-alpha or with high activity nAChR affects the modulation of neutrophil functions and its entry into tissue. Nicotine may deteriorate host defence in non-inflammatory situations.