Nicotine lowers TNF-alpha, IL-1b secretion and leukocyte accumulation via nAChR in rat stomach
TOXIN REVIEWS, vol.40, no.1, pp.17-24, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 40 Issue: 1
- Publication Date: 2021
- Doi Number: 10.1080/15569543.2020.1790604
- Journal Name: TOXIN REVIEWS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, BIOSIS, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, Veterinary Science Database
- Page Numbers: pp.17-24
- Keywords: Nicotine, TNF, IL-10, inflammation, stomach
- Dokuz Eylül University Affiliated: Yes
Abstract
Inflammatory suppressive effects of nicotine have been observed in inflammatory diseases. We aimed to investigate morphological damage and the changes in TNF-alpha, IL-1 beta, and IL-10 expression in the healthy stomach after long-term oral nicotine administration. Nicotine was added to the drinking water of Sprague Dawley rats for 6 weeks. Histological signs of damage, inflammatory cytokines, and nicotinic acetylcholine receptor (nAChR) levels were evaluated in the gastric tissues. There were no histological signs of inflammation in both groups. TNF-alpha and IL-1 beta were decreased in the nicotine-treated group. A positive correlation was found between TNF-alpha levels and infiltrated inflammatory cell count. nAChR levels were increased in the nicotine group. Long term nicotine administration upregulates and activates nAChR. The reduced TNF-alpha or with high activity nAChR affects the modulation of neutrophil functions and its entry into tissue. Nicotine may deteriorate host defence in non-inflammatory situations.