8-OH-DPAT STIMULATES GASTRIC-ACID SECRETION THROUGH A VAGAL-INDEPENDENT, ADRENAL-MEDIATED MECHANISM

GIDENER S., LEPARD K., STEPHENS R.

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.284, pp.19-24, 1995 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 284
  • Publication Date: 1995
  • Doi Number: 10.1016/0014-2999(95)00331-e
  • Journal Name: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.19-24
  • Keywords: 8-OH-DPAT ((+/-)-8-HYDROXY-2-(N-DIPROPYLAMINO)TETRALIN), ADRENAL GLAND, GASTROINTESTINAL SYSTEM, RAT, 5-HT1A RECEPTOR, ACID, RECEPTORS, RAT, AGONISTS, 5-HYDROXYTRYPTAMINE, ANTAGONISTS, SEROTONIN, 5-HT1A, AXIS
  • Dokuz Eylül University Affiliated: No

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a neuroendocrine component of the gastrointestinal tract. 5-HT1A receptors exist both in the brain and have been demonstrated autoradiographically in high density in the rat stomach. However, the physiologic role of 5-HT1A receptors in modulating gastric function is not known. The effect of the selective 5-HT1A receptor agonist, (+/-)-8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT), on gastric acid secretory function was compared to 5-HT in acute, urethane-anesthetized gastric-fistulated rats during pentagastrin infusion. 5-HT inhibited, but 8-OH-DPAT stimulated, gastric acid secretion in a dose-dependent manner. Bilateral cervical vagotomy or celiac ganglionectomy did not reverse the effect of 8-OH-DPAT on acid secretion. However, the enhancement of acid by 8-OH-DPAT was attenuated by acute adrenalectomy or close intra-arterial administration of spiperone, but not idazoxan. Thus, the data suggest that the selective 5-HT1A receptor agonist 8-OH-DPAT may augment gastric secretory function via an adrenal-dependent mechanism.