Synthesis of Cycloalk[b]indole Bearing Spiropiperidine Derivatives

GÜNDOĞDU HIZLIATEŞ C., Gulle S., Ergun Y.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.53, no.1, pp.249-254, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1002/jhet.2395
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.249-254
  • Keywords: Tetrahydrocarbazolones, sedative and hypnotic drugs, indole containing compounds, piperidinedione, AMINOGLUTETHIMIDE, OXIDATION, ALKALOIDS
  • Dokuz Eylül University Affiliated: Yes

Abstract

The novel heterocyclic compounds that have cycloalk[b]indole moiety bearing spiropiperidinone and spiropiperidinedione (3a, 3b, 3c, 5a, 5b, 8a, 8b, and 10a) were synthesized for the first time. The synthesis of spiropiperidinone and spiropiperidinedione structures was performed by a new method. These compounds are similar to sedative and hypnotic drugs such as methyprylon, glutethimide, and thalidomide.