Seminoma in a case of ovotesticular disease (true Hermaphrodith).


34th European Congress of Pathology, Basel, Switzerland, 03 September 2022, vol.481, no.481

  • Publication Type: Conference Paper / Summary Text
  • Volume: 481
  • City: Basel
  • Country: Switzerland
  • Dokuz Eylül University Affiliated: Yes


Background & objectives: Ovotesticular disorder is defined as the

presence of both ovaries and testes in the same person, regardless of

karyotype. Patients with ovotesticular disorder have a higher risk of

developing gonadal neoplasms such as gonadoblastoma or seminoma

than the general population.

Methods: The karyotype analysis of a 32-year-old male patient

with phenotype who was examined for bilateral abdominal undescended

testis was 46 XY. In his radiological examination, a

complex internal genital structure compatible with ovotestis was

detected. The patient whose operation material was examined in

our unit is presented with histopathological and clinical features.

Results: Macroscopically, the specimen consisted of bilobed gonadal

structures and a single cordial structure adjacent to it. In the histopathological

examination, in addition to seminoma, tissues including vesicle

seminalis, atrophic testis, tuba uterina, endometrium and endocervix

component were seen. Most of the structures thought to belong to the

female genital tract were not of the usual morphology, possibly due to

insufficient hormonal effect. Immunohistochemical markers contributed

greatly to the distinction of the organs and diagnosis. The patient,

who was diagnosed with ovotestis and Stage I seminoma based on

histopathological findings, received a single dose of carboplatin chemotherapy

and free of disease at 6th month of follow-up.

Conclusion: Ovostesticular disorder is a very rare sex developmental

disorder, with a 10% risk of germ cell tumour development

in 46XY and mosaicism cases.

As a result, orchiectomy is required in the presence of an undescended

testis or development of a tumour. Because male and

female genital organs have similar morphological and immunohistochemical

features, a multidisciplinary approach is required

for pathological examination.