Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

YILMAZ C. N., Pamfil D., Vasile C., Bibire N., Lupusoru R., Zamfir C., ...Daha Fazla

POLYMERS, cilt.9, sa.4, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3390/polym9040123
  • Dergi Adı: POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical-chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by "in vivo" tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2-7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease.