Clinical quiz: A pediatric case presenting with fever and diffuse myalgia

SOYLU A., Ozturk Y., Kasap B., Akman N., Turkmen M., Kavukcu S.

RHEUMATOLOGY INTERNATIONAL, vol.25, no.4, pp.314-316, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1007/s00296-004-0530-5
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.314-316
  • Keywords: familial Mediterranean fever, myalgia, protracted febrile myalgia syndrome, FAMILIAL MEDITERRANEAN FEVER, CHILDREN
  • Dokuz Eylül University Affiliated: Yes


Familial Mediterranean fever (FMF) is a multisystem disease characterized by recurrent polyserositis episodes seen in certain ethnic groups. In recent years the clinical picture of FMF has been expanded and severe myalgia is a frequently recognized component of the syndrome. Protracted febrile myalgia syndrome (PFMS), characterized by severe paralyzing myalgia, high fever, abdominal pain, diarrhea, arthritis/arthralgia, and transient vasculitic rashes mimicking Henoch-Schonlein purpura, was first described in patients with FMF in 1994. We describe an 11-year-old Turkish girl with a second attack of PFMS before being diagnosed as having FMF, emphasizing the importance of myalgia for the diagnosis of FMF even in the absence of other symptoms.