Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma

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Mungan M. U., Gurel D., Canda A. E., Tuna B., Yorukoglu K., Kirkali Z.

EUROPEAN UROLOGY, vol.50, no.1, pp.92-97, 2006 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 50 Issue: 1
• Publication Date: 2006
• Doi Number: 10.1016/j.eururo.2005.12.039
• Journal Name: EUROPEAN UROLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.92-97
• Keywords: kidney, renal cell carcinoma, renal intraepithelial neoplasia, pyelonephritis, infection, cyclooxygenase 2, CYCLOOXYGENASE-2 EXPRESSION, PROGNOSTIC-SIGNIFICANCE, CANCER, ANGIOGENESIS, PREVENTION, INHIBITORS, INVASION, LESIONS
• Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: The role of inflammation in carcinogenesis is unknown. To determine the relationship between cyclooxygenase 2 (COX-2) expression, inflammation, and carcinogenesis in human renal cell carcinoma (RCC), we looked for COX-2 expression in normal and pyelonephritic kidney, renal intratubular neoplasia (RIN), and RCC tissues.