Anti-inflammatory and Anti-apoptotic Effect of Valproic Acid and Doxycycline Independent from MMP Inhibition in Early Radiation Damage
BALKAN MEDICAL JOURNAL, vol.33, no.5, pp.488-495, 2016 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 33 Issue: 5
- Publication Date: 2016
- Doi Number: 10.5152/balkanmedj.2016.151304
- Journal Name: BALKAN MEDICAL JOURNAL
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.488-495
- Keywords: Matrix metalloproteinase, radiation, valproic acid, doxycycline
- Dokuz Eylül University Affiliated: Yes
Abstract
Background: Matrix metalloproteinase (MMP) inhibitors decrease inflammation in normal tissues and suppress cancer progress in normal tissues. Valproic acid (VA) and doxycycline (DX) are MMP inhibitors that have radio-protective effects. Their ability to inhibit MMPs in irradiated tissue is unknown and the role of MMPs in radio-protective effects has not been tested to date.