Anti-inflammatory and Anti-apoptotic Effect of Valproic Acid and Doxycycline Independent from MMP Inhibition in Early Radiation Damage

Hoşgörler F. U., Keles D., Tanriverdi-Akhisaroglu S., Inanc S., Akhisaroglu M., Cankurt Ü., ...More

BALKAN MEDICAL JOURNAL, vol.33, no.5, pp.488-495, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.5152/balkanmedj.2016.151304
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.488-495
  • Keywords: Matrix metalloproteinase, radiation, valproic acid, doxycycline, MATRIX METALLOPROTEINASES, ABDOMINAL IRRADIATION, BARRIER DISRUPTION, RECTAL MUCOSA, EXPRESSION, CANCER, DEGRADATION, INCREASES, ISCHEMIA, TUMOR
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Matrix metalloproteinase (MMP) inhibitors decrease inflammation in normal tissues and suppress cancer progress in normal tissues. Valproic acid (VA) and doxycycline (DX) are MMP inhibitors that have radio-protective effects. Their ability to inhibit MMPs in irradiated tissue is unknown and the role of MMPs in radio-protective effects has not been tested to date.