Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis


TAŞKAPAN H., Ersoy F. F., Passadakis P. S., Tam P., Memmos D. E., Katopodis K. P., ...More

CLINICAL NEPHROLOGY, vol.66, no.4, pp.247-255, 2006 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 4
  • Publication Date: 2006
  • Journal Name: CLINICAL NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.247-255
  • Keywords: vitamin D deficiency, serum 25(OH)D, dialysis, chronic renal failure, D INSUFFICIENCY, PARATHYROID-HORMONE, HYPOVITAMINOSIS-D, OSTEODYSTROPHY, HYPERPARATHYROIDISM, PREVALENCE, CALCIUM, KIDNEY, BONE, AGE
  • Dokuz Eylül University Affiliated: No

Abstract

The aim of this study was to evaluate the prevalence of vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with various demographic and renal osteodystrophy markers. Method: This cross-sectional, multicenter study was carried out in 273 PD patients with a mean age of 61.7 +/- 10.9 years and mean duration of PD 3.3 +/- 2.2 years. It included 123 female and 150 male patients from 20 centers in Greece and Turkey, countries that are on the same latitude, namely, 36 - 42 degrees north. We measured 25(OH)D-3 and 1.25(OH)(2)D-3 levels and some other clinical and laboratory indices of bone mineral metabolism. Results: Of these 273 patients 92% (251 patients) had vitamin D deficiency i.e. serum 25(OH)D-3 levels less than 15 ng/ml, 119 (43.6%) had severe vitamin D deficiency i.e. serum 25(OH)D-3 levels, less than 5 ng/ml, 132 (48.4%) had moderate vitamin D deficiency i.e. serum 25(OH)D3 levels, 5 - 15 ng/ml, 12 (4.4%) vitamin D insufficiency i.e. serum 25(OH)D3 levels 15 - 30 ng/ml and only 10 (3.6%) had adequate vitamin D stores. We found no correlation between 25(OH)D-3 levels and PTH, serum albumin, bone alkaline phosphatase, P, and Ca x P. In multiple regression analyses, the independent predictors of 25(OH)D-3 were age, presence of diabetes (DM-CRF), levels of serum calcium and serum 1.25(OH)(2)D-3- Conclusion: We found a high prevalence (92%) of vitamin D deficiency in these 273 PD patients, nearly one half of whom had severe vitamin D deficiency. Vitamin D deficiency is more common in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that these patients should be considered for vitamin D supplementation.