Research Information System
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.31, no.2, pp.350-357, 2011 (SCI-Expanded)
Objective: Aberrant Wnt signaling pathway activation and stabilization of beta-catenin protein is associated with tumorigenesis and human breast tumors. We have examined beta-catenin, cyclin D1, sFRP1 and sFRP2 expressions in the breast cancer and effects of these factors on prognostic parameters in patients with breast cancer. Material and Methods: One hundred and seventeen consecutive female malignant breast tumor patients were enrolled into the study. The mean age was 50.0 (+/- 18.0) years. Immunohistochemical staining method was used to investigate the stability and location of beta-catenin, expressions of sFRP1 and sFRP2 and cyclin D1 proteins. Results: Percentage expression of beta-catenin, siklin D1, sFRP1 and sFRP2 were 60.0 +/- 55.0, 40.0 +/- 64.0, 15.0 +/- 48.0 and 25.0 +/- 53.0, respectively. Menopausal status, progesterone receptor positivity, lymph node involvement and TNM staging did not show any statistically significant relation with the expression of beta-catenin, cyclin D1, sFRP1 or sFRP2. However, significantly higher percentages of expression of cyclin D1 were determined in patients showing estrogen receptor positivity and cerbB-2 over-expression (p=0.008). Additionally beta-catenin expression was significantly higher only in the p53-positive group (p=0.03). None of the parameters used in this study showed a significant effect on clinicopathological prognostic parameters. Conclusion: These findings suggested that expression levels and staining results of beta-catenin, cyclinD1, sFRP1 and sFRP2 in tumor cells were independent from histological grade, lymph node involvement, and TNM stage. We concluded that beta-catenin accumulation, cyclin DI, sFRP1 and sFRP2 expressions were not affected by the Wnt signaling pathway.