Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Cardiovascular Sciences, cilt.25, sa.1, ss.1-7, 2013 (Scopus)
Objective: Our objective in this study was to compare ischemia modified albumin (IMA) sensitivity with troponin and creatine kinase isoenzyme MB (CK MB) in myocardial is chemia formed as a result of ischemia reperfusion in coronary by pass surgery. Material and Methn ods: 30 patients applying to our clinic within 6 months, to whom elective coronary artery bypass grafting (CABG) will be applied with the diagnosis of coronary artery disease (CAD), have been examined. Mean age of our patients was found to be 63,8±8,3 year for males (26 patients) and 58,5±3,4 (4 patients). Blood samples were taken from venous jugular catheter after anesthesia in duction, before (Ti), in the end (12), and 1 hour after (13) cardiopulmonary bypass (CPB). CK MB, IMA, albumin, and troponin I measurements were carried out. Results: The three biochemical ischemia markers showed an increase as a result of reperfusion damage. IMA values were meas ured as 0.595±0.051 absorbance values (ABSU), 0.639±0.049 ABSU, and 0.589±0.47 ABSU in groups respectively. The increase in IMA measurements before and after CPB was found to be meaning ful with myocardial ischemia exposure (p-O,002). IMA measurements at the pump outlet and 1 hour later were found to be meaningful with myocardial reperfhsion result (p-O,001). When com pared to IMA measurements before and 1 hour after CPB, it was determined that it reached its baseline value after ischemic reperfusion (p-O,899). Conclusion: In this study, the ischemia modi fied albumin showed a rapid increase after CABG when compared to troponin and CK MB. It prom ises hope for early diagnosis of the myocardial damage. Copyright © 2013 by Türkiye Klinik leri.