Chemopreventive efficacies of rosiglitazone, fenretinide and their combination against rat mammary carcinogenesis
CLINICAL & TRANSLATIONAL ONCOLOGY, cilt.11, sa.4, ss.243-249, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 4
- Basım Tarihi: 2009
- Doi Numarası: 10.1007/s12094-009-0347-5
- Dergi Adı: CLINICAL & TRANSLATIONAL ONCOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.243-249
- Anahtar Kelimeler: Chemoprevention, DMBA, Rosiglitazone, Fenretinide, Mammary carcinogenesis
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and retinoic acid receptors (RAR/RXR) belong to the nuclear steroid receptor family. In vitro studies have suggested that PPAR-gamma ligands are highly effective in preventing mammary tumours and these effects are enhanced by some retinoids. However, in vivo anti-initiator and anti-promoter efficacies of this combination are not clear.