SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF SOME 3,6-DISUBSTITUTED THIAZOLO[3,2-B][1,2,4]TRIAZOLES

EROL D., CALIS U., DEMIRDAMAR R., YULUG N., ERTAN M.

JOURNAL OF PHARMACEUTICAL SCIENCES, vol.84, no.4, pp.462-465, 1995 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 4
  • Publication Date: 1995
  • Doi Number: 10.1002/jps.2600840414
  • Journal Name: JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, Analytical Abstracts, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.462-465
  • Dokuz Eylül University Affiliated: No

Abstract

Some new 2,3-dihydro-9-hydroxy-6-phenyl-3-(4-substituted-(phenylthiazolo[3,2-b][1,2,4]triazole derivatives were synthesized as antifungal agents. After their structures were confirmed by microanalysis and IR and NMR spectral analysis, their antifungal activities against Candida albicans, Candida parapsilosis, Candida stellatoidea, and Candida pseudotropicalis were investigated. Contrary to our expectations, all proved to have poor antifungal activities. Because 2,4-dihydro-3H-1,2,4-triazol-3-ones are a new class of anticonvulsant agents, a series of thiazolo[3,2-b][1,2,4]triazoles was evaluated for anticonvulsant activity and observed as potential anticonvulsant candidates. All compounds examined exhibited activity against both maximal electroshock and pentylene tetrazole-induced seizures in mice.