Evaluation of infection imaging potential of I-131-labeled imidazolium salt
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.315, no.3, pp.487-492, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 315 Issue: 3
- Publication Date: 2018
- Doi Number: 10.1007/s10967-017-5691-2
- Journal Name: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.487-492
- Keywords: Imidazolium salt, I-131, In vitro binding, Infection detection, Biodistribution, Staphylococcus aureus
- Dokuz Eylül University Affiliated: Yes
Abstract
Effective antimicrobial compounds are necessary due to increased resistance of antibiotics against microorganisms causing infectious diseases. In this study, imidazolium-TFSI salt [ITFSI: octyl-bis(3-methylimidazolium)-di(bis(trifluoromethane)sulfonimide)] was labeled with I-131 with high efficiency. In vitro uptake experiments of I-131-ITFSI showed high uptake in gram-positive Staphylococcus aureus bacteria. I-131-ITFSI was also evaluated for comparison between bacterial infection and sterile inflammation by in vivo studies. The biodistribution results revealed that I-131-ITFSI might be used as a nuclear imaging agent for detection of bacterial infection.