Akademik Veri Yönetim Sistemi
Polyhedron, cilt.281, 2025 (SCI-Expanded)
The ruthenium, palladium, and silver complexes with N-heterocyclic carbene (NHC) ligands have been widely studied for promising anticancer activities, and they have been found to exhibit strong cytotoxic activity toward a range of cancer cells. However, the ruthenium and palladium NHC complexes have been less studied compared to silver and gold NHC complexes as antimicrobial agents. Herein, Ag, Ru, and Pd complexes of a benzimidazol-2-ylidene ligand bearing p-nitrobenzyl and diisopropylaminoethyl groups were synthesized and characterized by FT-IR, 1H NMR and 13C NMR spectroscopy, elemental analysis and mass spectrometry. The molecular and crystal structures of 2 and 4 were confirmed by the single-crystal X-ray diffraction (SC-XRD) method. All compounds were tested for antibacterial and antifungal activities and the minimum inhibitory concentrations were determined. The results indicates that some compounds exert effective antibacterial activity against Gram-negative and four Gram-positive bacterial strains and two yeast strains. Ag complex 2 had great antibacterial activity against Staphylococcus aureus at MIC value of 12.5 μg/mL. However, the presence of ruthenium in the structure of the compounds increased overall antibacterial and antifungal activity.