Research Information System
Journal of Neurological Sciences, vol.30, no.4, pp.756-766, 2013 (SCI-Expanded)
In this study, it was aimed to assess effect of classical micro-suturing techniques combined with cyanoacrylate, used in nerve repair, on nerve regeneration in histopathological manner and to evaluate whether it could be safely used in peripheral nerve surgery. Adult Wistar-Albino female rats were used in this study. Animals were assigned into 4 groups for surgical processes as follows: Group 1: Control group (n=7); External circumferential neurolysis Group 2: Experiment group (n=7); Repair with 4 epineural sutures. Group 3: Experiment group (n=7); Repair with cyanoacrylate Group 4: Experiment group (n=7); combined group Histopathologically, it was seen that there was no vacuolar degeneration, foreign body type tissue reaction or fibrosis in the nerves of subjects in the control group. Moreover, it was found that there were findings of vacuolar degeneration, foreign body type tissue reaction and fibrosis in all experiments group in a similar manner. However, it was found that there was a statistically significant difference regarding grade results of vacuolar degeneration, fibrosis and foreign body type tissue reaction between control group and classical suturing, cyanoacrylate or combined groups (p<0.05). In conclusion, it has been thought that cyanoacrylate is a feasible method for peripheral nerve surgery; as it can be easily applied at conditions where surgical suturing is challenging; it reduces the trauma exposed by nerve endings; it provides easy identification of nerve endings during secondary repair, which are contaminated and could not be primarily repaired; it shortens the procedure time; it is cost-effective and; it easy to learn.