Tuberculosis despite latent infection screening and treatment in patients receiving TNF inhibitor therapy


Kaptan Y., SUNER KARAKÜLAH A., Tas M. N., OKSEL F., AKSU K., SAYINER A.

CLINICAL RHEUMATOLOGY, vol.40, no.9, pp.3783-3788, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.1007/s10067-021-05697-5
  • Journal Name: CLINICAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.3783-3788
  • Keywords: Hepatotoxicity, Isoniazid, TNF inhibitor, Treatment, Tuberculosis
  • Dokuz Eylül University Affiliated: No

Abstract

Introduction Although latent tuberculosis infection (LTBI) treatment is given before anti-tumor necrosis factor (TNF) treatment, tuberculosis (TB) still develops in these patients and the risk factors are not well known. Besides, there is little data on the safety of isoniazid (INH) treatment in this group of patients. This study aimed to determine the risk factors for the development of tuberculosis and the safety of LTBI in such patients.