Prognostic Factors and Scoring Systems in Chronic Myelomonocytic Leukemia: A Retrospective Analysis of 37 Patients


DEMİRKAN F., ALACACIOĞLU İ., Piskin O., ÖZSAN G. H., ÖZCAN M., ÜNDAR B.

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, vol.18, no.4, pp.193-200, 2008 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2008
  • Journal Name: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.193-200
  • Keywords: Chronic myelomonocytic leukemia, Myelodysplastic syndrome, Scoring systems, Prognostic factors, HEALTH-ORGANIZATION CLASSIFICATION, PRIMARY MYELODYSPLASTIC SYNDROMES, SINGLE INSTITUTION, PROPOSALS, CMML, SURVIVAL
  • Dokuz Eylül University Affiliated: Yes

Abstract

Main objective of this study was to evaluate hematological, clinical and demographic features of our chronic myelomonocytic leukemia (CMML) patients according to different classification systems and prognostic variables. Thirty-seven consecutive patients with CMML diagnosed between February 1994 and December 2005 were evaluated retrospectively. Male and female ratio was 29/8. The median age at diagnosis was 72. Median follow-up time for all patients was 12 months (1-119 months). 70.3% of patients were classified as CMML-MP, others were classified as CMML-MD type according to FAB. When they were reclassified according to WHO, 86.5% of them were CMML-I and 13.5% were CMML-II. Karyotyping analysis could be made in only 22 patients.