Akademik Veri Yönetim Sistemi
Annals of Medical Sciences, cilt.7, sa.2, ss.78-83, 1998 (Scopus)
Background: In head and neck region there are many types of benign and malignant verrucal papillary lesions which can be hardly differentiated on their histopathologic findings. In this study verrucous carcinomas, well differentiated conventional type squamous cell carcinomas and epithelial hyperplasias which can show verrucal morphology, were evaluated in terms of their association with Human Papilloma Virus and in terms of their proliferative activity patterns expressed by proliferating cell nuclear antigene. Expression of Human Papilloma Virus and the help of proliferative activity pattern in the differential diagnosis of the lesions were discussed. Methods: Five of 6 verrucous carcinomas, 9 well differentiated conventional type squamous cell carcinomas and 5 epithelial hyperplasias were stained with Human Papilloma Virus Antibody and antibody against Proliferating Cell Nuclear Antigene by immunohistochemical method. Cytoplasmic and nuclear staining with Human Papilloma Virus antibody and staining pattern of Proliferating Cell Nuclear Antigene was evaluated. Results: Three of 9 squamous cell carcinomas, four of 5 epithelial hyperplasias but non of the verrucous carcinomas were positive for Human Papilloma Virus. Proliferating Cell Nuclear Antigene staining was restricted to basal cells in epithelial hyperplasias and verrucous carcinomas while it was scattered in squamous cell carcinomas. Conclusion: Staining pattern of proliferative cells with proliferative markers in verrucuos carcinomas, and squamous cell carcinomas may help in the distinction of these tumors. Association of Human Papilloma Virus with squamous cell carcinomas and epithelial hyperplasias, but not with verrucous carcinomas was shown in our study. The role of Human Papilloma Virus on carcinogenesis should be discussed in series including normal mucosa devoid of tumor which can also clarify the real frequency of this virus in non tumoral conditions.