Matrix metalloproteinase-2 expression in laryngeal preneoplastic and neoplastic lesions

SARIOĞLU S., Ozer E., Kirimca F., Sis B., Pabuccuoglu U.

PATHOLOGY RESEARCH AND PRACTICE, vol.197, no.7, pp.483-486, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 197 Issue: 7
  • Publication Date: 2001
  • Doi Number: 10.1078/0344-0338-00115
  • Journal Name: PATHOLOGY RESEARCH AND PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.483-486
  • Keywords: carcinoma in situ, dysplasia, larynx, matrix metalloproteinase, squamous cell carcinoma
  • Dokuz Eylül University Affiliated: No

Abstract

Matrix metalloproteinase-2 (MMP-2), a member of gelatinases, is particularly important in the digestion of nonfibrillary and denaturated collagens; thus, it may play a role in tissue remodeling and in the invasion of malignant cells. The expression of MMP-2 has not yet been described in preneoplastic lesions of the larynx thus far. The purpose of this study was to evaluate whether the expression of MMP-2 plays a role in early laryngeal carcinogenesis.