Matrix metalloproteinase-2 expression in laryngeal preneoplastic and neoplastic lesions

SARIOĞLU S., Ozer E., Kirimca F., Sis B., Pabuccuoglu U.

PATHOLOGY RESEARCH AND PRACTICE, cilt.197, sa.7, ss.483-486, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 197 Sayı: 7
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1078/0344-0338-00115
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.483-486
  • Anahtar Kelimeler: carcinoma in situ, dysplasia, larynx, matrix metalloproteinase, squamous cell carcinoma
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Matrix metalloproteinase-2 (MMP-2), a member of gelatinases, is particularly important in the digestion of nonfibrillary and denaturated collagens; thus, it may play a role in tissue remodeling and in the invasion of malignant cells. The expression of MMP-2 has not yet been described in preneoplastic lesions of the larynx thus far. The purpose of this study was to evaluate whether the expression of MMP-2 plays a role in early laryngeal carcinogenesis.