Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats

Dundar, Hatice; KİRAY, MÜGE; KIR, MUSTAFA; KOLATAN, HATİCE; BAĞRIYANIK, HÜSNÜ; ALTUN, ZEKİYE; AKTAŞ, SAFİYE; ELLİDOKUZ, HÜLYA; YILMAZ, OSMAN; Mutafoglu, Kamer; Olgun, HATİCE

doi:10.1016/j.arcmed.2016.11.008

Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats

Dundar H. A., KİRAY M., KIR M., KOLATAN H. E., BAĞRIYANIK H. A., ALTUN Z. S., ...Daha Fazla

ARCHIVES OF MEDICAL RESEARCH, cilt.47, sa.7, ss.506-514, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 47 Sayı: 7
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.arcmed.2016.11.008
Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.506-514
Anahtar Kelimeler: Acetyl-L-carnitine, Apoptosis, Doxorubicin cardiotoxicity, Echocardiography, Ultrastructure
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background and Aims. Anthracyclines are one of the most preferred agents in practical pediatric oncology despite their dose-dependent cardiotoxic effects. The aim of this study was to investigate whether or not acetyl-L-carnitine (ALCAR) has protective effects on doxorubicin (DOX)-induced cardiotoxicity.