Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats

Dundar H. A., KİRAY M., KIR M., KOLATAN H. E., BAĞRIYANIK H. A., ALTUN Z. S., ...Daha Fazla

ARCHIVES OF MEDICAL RESEARCH, cilt.47, sa.7, ss.506-514, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 7
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.arcmed.2016.11.008
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.506-514
  • Anahtar Kelimeler: Acetyl-L-carnitine, Apoptosis, Doxorubicin cardiotoxicity, Echocardiography, Ultrastructure, ALPHA-LIPOIC ACID, OXIDATIVE STRESS, DAMAGE, BRAIN, METABOLISM, MODULATION, ADRIAMYCIN, MECHANISMS, TOXICITY, EXPOSURE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background and Aims. Anthracyclines are one of the most preferred agents in practical pediatric oncology despite their dose-dependent cardiotoxic effects. The aim of this study was to investigate whether or not acetyl-L-carnitine (ALCAR) has protective effects on doxorubicin (DOX)-induced cardiotoxicity.