The correlation between T regulatory cells and autologous peripheral blood stem cell transplantation in multiple myeloma

Erçetin A. P., Aktaş S., Piskin O., Ateş H., Zadeoglulari Z. F., Turgut N. H., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, sa.2, ss.107-114, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/tjh.2011.26
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.107-114
  • Anahtar Kelimeler: T Regulatory cells, multiple myeloma, autologous bone marrow transplantation, CD200, programmed death-1, THERAPEUTIC TARGET, STAGING SYSTEM, PD-L1, CD200
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Multiple myeloma (MM) is characterized by malignant proliferation of plasmocytes and their precursors. T regulatory cells (Tregs) have a role in immunosuppression and control of autoimmunity, and are currently an important topic in the study of immune response to tumor cells. The correlation between Tregs and autologous peripheral blood stem cell transplantation (APBSCT) in MM has not been studied. The aim of this study was to compare CD4+CD25+FOXP3+ Treg, CD200, and PD-1 levels in MM patients that did and did not undergo APBSCT.