Emecen A. N., Şiyve N., Unal B.
EUROPEAN JOURNAL OF PUBLIC HEALTH, cilt.33, sa.Supplement_2, ss.144, 2023 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
33
Sayı:
Supplement_2
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Basım Tarihi:
2023
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Doi Numarası:
10.1093/eurpub/ckad160.365
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Dergi Adı:
EUROPEAN JOURNAL OF PUBLIC HEALTH
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ABI/INFORM, Abstracts in Social Gerontology, Agricultural & Environmental Science Database, CAB Abstracts, CINAHL, Educational research abstracts (ERA), EMBASE, Food Science & Technology Abstracts, Index Islamicus, MEDLINE, PAIS International, Political Science Complete, Pollution Abstracts, Psycinfo, Public Affairs Index, Social services abstracts, Sociological abstracts, Veterinary Science Database, Worldwide Political Science Abstracts
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Sayfa Sayıları:
ss.144
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Dokuz Eylül Üniversitesi Adresli:
Evet
Özet
Abstract
Background
Cardiovascular diseases (CVD) is a major cause of death globally, and accurate risk assessment is important for identifying high-risk individuals. This study aimed to validate the laboratory-based Globorisk score for predicting CVD in the Turkish population and to develop a Turkish population-specific model.
Methods
We analyzed data from Turkey's Chronic Diseases and Risk Factors study, which examined CVD incidence from 2011 until 2017. After excluding those with prior CVD history, a total of 7239 individuals aged 40 to 80 years were included in the analysis. The performance of Globorisk in predicting CVD was assessed using the C-index. With demographic, dietary, anthropometric and Globorisk variables; we used backward stepwise logistic regression to select the final model (Turkish CVD-TCVD). Lastly, the TCVD model was internally validated and calibrated with 200 bootstrap replicates.
Results
Out of 7239 participants (mean age: 53.9±10.3), women: 52.3%); 766 developed CVD within six years (cumulative incidence rate: 10.6%). The C-index of the Globorisk was 0.72 with sensitivity and specificity being 68.2% and 67.3%. In the final TCVD model, backward stepwise selection identified age (odds ratio-OR: 1.06, 95% Cl: 1.05-1.07), diabetes (OR:1.83, 1.47-2.28), body mass index (OR:1.02, 1.01-1.04), high waist-hip ratio (OR:1.37, 1.13-1.66) and systolic blood pressure (OR:1.01, 1.00-1.01) as significant predictors for CVD. C-index was 0.73 with sensitivity and specificity being 72.9%, and 62.9%. Examination of the calibration plot showed signs of overprediction when the actual CVD probability was >20%.
Conclusions
Laboratory-based Globorisk score had a good fit in the Turkish population. TCVD model had better sensitivity than Globorisk. Adding of waist-hip ratio to the Globorisk score could improve predictive CVD models in the Turkish population.
Key messages
• External validation of laboratory-based Globorisk showed good predictive accuracy in the Turkish population.
• Although more challenging to measure, adding of waist-hip ratio to the laboratory-based Globorisk score could improve predictive cardiovascular disease models in the Turkish population.