Are cytokines and cortisol important predictors for the severity of pediatric croup: A case control study

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Uzum O., Caglar A., Küme T., Sayıner A. A., Er A., Akgul F., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.59, sa.3, ss.281-287, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.24953/turkjped.2017.03.008
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.281-287
  • Anahtar Kelimeler: children, croup, cytokines, cortisol, PLATELET-ACTIVATING-FACTOR, RECURRENT CROUP, VIRAL CROUP, ANAPHYLAXIS, CHILDREN, ATOPY, BRONCHIOLITIS, ASSOCIATION, CHILDHOOD, ASTHMA
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study is to investigate the role of cytokines (TNF-α, IL-6, IL-10, and PAF), cortisol, and IgE in the pathogenesis of croup and the factors determining its clinical severity. Patients diagnosed with croup at the Pediatric Emergency Department were included and thirty healthy children were included as a control group. Patients’ demographic characteristics, clinical findings, recurrent croup history, and patient-family atopy history were recorded. Patients were grouped according to the Westley croup scoring system. Blood samples were taken from the control group and the patients for cytokines and cortisol. Respiratory pathogens were studied with PCR. Sixty-nine pediatric cases who were diagnosed as croup were included in the study (34 mild, 31 moderate, 4 severe). Group comparisons were made in terms of mild and moderate/severe groups. In the moderate/severe group, IL-10 and cortisol levels were higher than the mild group. The moderate/severe cortisol levels between 12:00am-6:00pm were found to be higher. PAF and TNF-alpha levels were detected to be higher in patients with a history of atopy. Viral agents were isolated in 45 patients; rhinovirus PCR tests were positive in 22 patients.
In this study, rhinovirus was the most common etiology for croup. Increased levels of IL-10 and cortisol in the moderate/severe group indicate that different systemic and local mechanisms may play a role in the pathogenesis of croup.