Anti-inflammatory activity of Anthemis aciphylla var. aciphylla Boiss.
TURKISH JOURNAL OF BIOLOGY, vol.35, no.6, pp.757-762, 2011 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 35 Issue: 6
- Publication Date: 2011
- Doi Number: 10.3906/biy-1006-15
- Journal Name: TURKISH JOURNAL OF BIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.757-762
- Keywords: Anthemis aciphylla, anti-inflammatory activity, carrageenin, paw edema, cotton pellet
- Dokuz Eylül University Affiliated: Yes
Abstract
Ethanolic (EEAA) and sesquiterpene lactone (SEAA) extracts of the aerial parts of Anthemis aciphylla var. aciphylla Boiss. (Asteraceae) were evaluated for anti-inflammatory activity on carrageenin-induced paw edema (acute model) and cotton pellet-induced granuloma (chronic model) in rats. In carrageenin-induced paw edema, EEAA and SEAA at intraperitoneal doses of 50, 100, and 200 mg/kg dose-dependently inhibited the paw edema. In cotton pellet-induced granuloma, the oral administration of EEAA and SEAA at 50, 100, and 200 mg/kg dosages was also found to significantly inhibit granuloma tissue formation.