Anti-inflammatory activity of Anthemis aciphylla var. aciphylla Boiss.

BALTACI S., KOLATAN H. E., YILMAZ O., KIVÇAK B.

TURKISH JOURNAL OF BIOLOGY, vol.35, no.6, pp.757-762, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2011
  • Doi Number: 10.3906/biy-1006-15
  • Journal Name: TURKISH JOURNAL OF BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.757-762
  • Keywords: Anthemis aciphylla, anti-inflammatory activity, carrageenin, paw edema, cotton pellet, MECHANISM, DRUGS, TURKEY, EDEMA
  • Dokuz Eylül University Affiliated: Yes

Abstract

Ethanolic (EEAA) and sesquiterpene lactone (SEAA) extracts of the aerial parts of Anthemis aciphylla var. aciphylla Boiss. (Asteraceae) were evaluated for anti-inflammatory activity on carrageenin-induced paw edema (acute model) and cotton pellet-induced granuloma (chronic model) in rats. In carrageenin-induced paw edema, EEAA and SEAA at intraperitoneal doses of 50, 100, and 200 mg/kg dose-dependently inhibited the paw edema. In cotton pellet-induced granuloma, the oral administration of EEAA and SEAA at 50, 100, and 200 mg/kg dosages was also found to significantly inhibit granuloma tissue formation.