Distribution of LDL subgroups in patients with hyperlipidemia
TURKISH JOURNAL OF MEDICAL SCIENCES, vol.46, no.2, pp.374-380, 2016 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 46 Issue: 2
- Publication Date: 2016
- Doi Number: 10.3906/sag-1410-40
- Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.374-380
- Keywords: Hyperlipidemia, atherosclerosis, small dense low-density lipoproteins
- Dokuz Eylül University Affiliated: Yes
Abstract
Background/aim: Low-density lipoproteins (LDLs) have been shown to be a major risk factor for coronary artery disease. Multiple distinct subspecies have been identified among LDL particles on the basis of differences in size, density, and chemical composition. Particles with a diameter of <25.5 nm are defined as small dense LDL (sdLDL) and have been shown to be associated with increased risk of coronary disease. Subjects with predominance of sdLDL (pattern B) tend to have higher levels of triglyceride (TG) and lower levels of high-density lipoprotein cholesterol (HDL-C). In this study, we investigated the distribution of LDL subgroups in subjects with different types of hyperlipidemia, such as hypertriglyceridemia (hyperTG), hypercholesterolemia (hyperCHO), and combined hyperlipidemia (HL).