Bis[N,N '-bis(anilino)glioximato]platinum(II) complex: synthesis, characterization and biological activity

Gulumsek O. E., Baykal E. E., Kucukpolat C., Onal E., BALÇIK ERÇİN P., YAĞCI T., ...More

JOURNAL OF COORDINATION CHEMISTRY, vol.75, no.1-2, pp.197-210, 2022 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 1-2
  • Publication Date: 2022
  • Doi Number: 10.1080/00958972.2022.2028779
  • Journal Name: JOURNAL OF COORDINATION CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Metadex
  • Page Numbers: pp.197-210
  • Keywords: vic-Dioxime, platinum(II) complex, X-ray, HSQC, HMBC, anticancer activity, PLATINUM COMPLEXES, MOLECULAR-STRUCTURE, CRYSTAL-STRUCTURE, ESCHERICHIA-COLI, METAL-COMPLEXES, CELL-DIVISION, VIC-DIOXIMES, INHIBITION, COBALT(II), CHEMISTRY
  • Dokuz Eylül University Affiliated: Yes

Abstract

N,N '-bis(aniline)glyoxime (H2L, 1) has been prepared from aniline and (E,E)-dichloroglyoxime (DCGO) or (E,E)-dibromoglyoxime (DBGO). The reaction of N,N '-bis(aniline)glyoxime (H2L, 1) with solution of PtCl2 in dimethylsulfoxide produced brown-colored bis(E,E-dioximato)platinum(II) complex {[(E,E)-Pt(HL)(2)]} (1a) featuring N-chelating ligand. The crystal structure of this complex has been identified by X-ray diffraction on a single-crystal. In vitro assay of proliferation, cell death, DNA-damage and cell uptake activities of 1 and 1a were tested in HCC cell lines, SNU-182 and HUH-7. 1a has an anti-proliferative effect in HCC cells, however, 1 did not. Furthermore, the cellular uptake of 1a was relatively high compared to cisplatin cellular platinum levels. Compatible with proliferation and cellular uptake results, treatment with 1a caused DNA-damage and subsequent apoptosis in both HCC cell lines.