Evaluation of Serum Neutrophil Gelatinase-Associated Lipocalin, Cystatin C, and Clusterin Concentrations in Neonatal Calf Diarrhea

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Tümer K. Ç., Polat Dinçer P. F.

LARGE ANIMAL REVIEW, vol.30, no.1, pp.7-11, 2024 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2024
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.7-11
  • Dokuz Eylül University Affiliated: Yes


Neonatal diarrhea adversely affects calf growth, overall health, and productivity. Many factors such as poor environmental con-
ditions, less colostrum intake, infectious and parasitic factors contribute to the development of calf diarrhea. Diarrhea, whic
is one of the most important causes of calf deaths all over the world, causes significant economic losses if it is not correctl
y di-
agnosed and appropriate treatment is not initiated. Systemic inflammatory response and kidney dysfunction are crucial com-
ponents associated with the pathogenesis and progression of ne
onatal diarrhea. Early detection and management of these con-
ditions are essential for minimizing their detrimental effects and im
proving calf health outcomes. However, traditional biomark
such as haptoglobin and creatinine have limitations in terms of se
nsitivity, specificity, and accuracy. This study aimed to inv
tigate the potential of emerging markers, including neutroph
il gelatinase-associated lipocalin (NGAL), cystatin C, and clusteri
in assessing inflammation and kidney injury in neonatal calves with diarrhea. The levels of NGAL, cystatin C, clusterin, hapto-
globin, and creatinine were measured and compared among the groups. The results showed no significant differences in NGAL
and cystatin C concentrations between the diarrheic calves and healthy calves. However, there was a significant increase in ser
clusterin concentration in calves infected with
Escherichia coli
E. coli
) compared to other pathogen-infected calves and healthy
calves. Moreover, a moderate positive correlation was observed between clusterin and creatinine concentrations, suggesting a po
tential association between clusterin and kidney injury. These findings highlight the potential of clusterin as a marker for ki
ney dysfunction in neonatal calves with diarrhea, particularly in cases of
E. coli
infection. This study will contribute to the di-
agnosis and treatment in field conditions, while shedding light on the parameters used in the early diagnosis of calf diarrhea.
Further research is needed to investigate the underlying mechanisms and evaluate the diagnostic and prognostic value of clus-
terin in assessing the severity and progression of kidney dysfunction in affected calves.