Evaluation of Serum Neutrophil Gelatinase-Associated Lipocalin, Cystatin C, and Clusterin Concentrations in Neonatal Calf Diarrhea

LARGE ANIMAL REVIEW, cilt.30, sa.1, ss.7-11, 2024 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 30 Sayı: 1
Basım Tarihi: 2024
Dergi Adı: LARGE ANIMAL REVIEW
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Veterinary Science Database
Sayfa Sayıları: ss.7-11
Dokuz Eylül Üniversitesi Adresli: Evet

Neonatal diarrhea adversely affects calf growth, overall health, and productivity. Many factors such as poor environmental con-

ditions, less colostrum intake, infectious and parasitic factors contribute to the development of calf diarrhea. Diarrhea, whic

is one of the most important causes of calf deaths all over the world, causes significant economic losses if it is not correctl

y di-

agnosed and appropriate treatment is not initiated. Systemic inflammatory response and kidney dysfunction are crucial com-

ponents associated with the pathogenesis and progression of ne

onatal diarrhea. Early detection and management of these con-

ditions are essential for minimizing their detrimental effects and im

proving calf health outcomes. However, traditional biomark

ers

such as haptoglobin and creatinine have limitations in terms of se

nsitivity, specificity, and accuracy. This study aimed to inv

es-

tigate the potential of emerging markers, including neutroph

il gelatinase-associated lipocalin (NGAL), cystatin C, and clusteri

in assessing inflammation and kidney injury in neonatal calves with diarrhea. The levels of NGAL, cystatin C, clusterin, hapto-

globin, and creatinine were measured and compared among the groups. The results showed no significant differences in NGAL

and cystatin C concentrations between the diarrheic calves and healthy calves. However, there was a significant increase in ser

clusterin concentration in calves infected with

Escherichia coli

(

E. coli

) compared to other pathogen-infected calves and healthy

calves. Moreover, a moderate positive correlation was observed between clusterin and creatinine concentrations, suggesting a po

tential association between clusterin and kidney injury. These findings highlight the potential of clusterin as a marker for ki

ney dysfunction in neonatal calves with diarrhea, particularly in cases of

E. coli

infection. This study will contribute to the di-

agnosis and treatment in field conditions, while shedding light on the parameters used in the early diagnosis of calf diarrhea.

Further research is needed to investigate the underlying mechanisms and evaluate the diagnostic and prognostic value of clus-

terin in assessing the severity and progression of kidney dysfunction in affected calves.