Comparison between serum neopterin, procalcitonin, high-sensitivity C-reactive protein concentrations and erythrocyte sedimentation rates of patients with brucellosis and extracellular bacterial infections

Gunal O., Barut S., Sogut E., Duygu F., Etikan I., Parlak E., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.39, sa.1, ss.37-42, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5505/tjb.2014.72602
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.37-42
  • Anahtar Kelimeler: Brucellosis, neopterin, procalcitonin, High-sensitivity C-reactive protein
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Objectives: The aim of this study was to evaluate neopterin (NPT), procalcitonin (PCT), erythrocyte sedimentation rates (ESR) and high-sensitivity C-reactive protein (hs-CRP) levels in brucellosis and to compare them with extracellular bacterial infections. Methods: In the study, a total of 89 patients, 50 patients (study group) with acute brucellosis and 39 patients with extracellular bacterial infections (EI group), were included. In EI group, 21 patients had upper urinary tract infection (UTI) while 18 patients had skin and soft tissue infection (SSTI). As well as the appropriate clinic, the patients with positive blood cultures for Brucella spp. or Standard Tube Agglutination test >= 1/160 were diagnosed with brucellosis. Brucellosis and EI groups were compared in terms of ESR, NPT, PCT and hs-CRP. Results: In study group mean age was 40.64 +/- 1.86 (18-66) and in EI group mean age was 51.61 +/- 2.68 (18-82). After comparison analysis; ESR (16.5 +/- 1.75 vs 40.17 +/- 4.52 mm/h, p=0.0001) and hs-CRP (40 +/- 8 vs 280 +/- 30 mg/L, p=00001) were found lower in the study group than EI group while there was no difference between groups in terms of PCT (p=0.887) and NPT (p=0.688). Additionally, PCT values were higher in patients with UTI than SSTI. Conclusion: It was seen that NPT and PCT values in brucellosis were not different from extracellular bacterial infections, whereas higher ESR and hs-CRP values could be seen in patients with extracellular bacterial infections. Also, higher PCT values could be seen in patients with urinary tract infections compared to patients with skin and soft tissue infections.