An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

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ÇAVUŞOĞLU T., Dariverenli E., VURAL K., EKERBİÇER N., ULMAN C., ÖLMEZ E., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.45, no.4, pp.397-404, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1515/tjb-2019-0224
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.397-404
  • Keywords: Erythrocyte sedimentation rate, diurnal variation, preanalytical factors, fasting, satiety, INSULIN-RESISTANCE, PLASMA-GLUCOSE, NITRIC-OXIDE, STREPTOZOTOCIN, CHOLESTEROL, MECHANISMS, SEROTONIN, STRESS, 5-HT
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: Type 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.