DELETION-6Q IN 3 CASES OF MIXED-TYPE LIPOSARCOMA IN ADDITION TO T(12-16)(Q13-P11)

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ALTUNGOZ O., MELONI A., PEIER A., ZALUPSKI M., SPANIER S., BROOKS J., ...More

CANCER GENETICS AND CYTOGENETICS, vol.79, no.2, pp.104-110, 1995 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 79 Issue: 2
• Publication Date: 1995
• Doi Number: 10.1016/0165-4608(94)00180-j
• Journal Name: CANCER GENETICS AND CYTOGENETICS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier
• Page Numbers: pp.104-110
• Dokuz Eylül University Affiliated: Yes

Abstract

We report the cytogenetic findings in three mixed liposarcoma following short-term cultures. During the course of cytogenetic investigation of various types of liposarcomas, we observed an interstitial deletion of the long arm of chromosome 6 together with the translocation (12;16) (q13;p11) in three tumors. Translocation (12;16) is associated with myxoid and mixed (myxoid/round cell) liposarcomas, although deletion of chromosome 6 has been observed in only a few of these tumors. Our findings suggest that del(6), as an additional change in myxoid liposarcoma, is probably related to tumor progression.