Heparin treatment increases thioredoxin interacting protein expression in hepatocellular carcinoma cells

Gunes A., İŞCAN E., Topel H., Avci S. T., GÜMÜŞTEKİN M., Erdal E., ...Daha Fazla

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, cilt.65, ss.169-181, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.biocel.2015.05.025
  • Dergi Adı: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.169-181
  • Anahtar Kelimeler: Heparin, HCC, TXNIP, ChoRE, ChoRE associated proteins, CARBOHYDRATE RESPONSE ELEMENT, GLUCOSE, TXNIP, SULFATE, MET, GROWTH, MLX, ANTITHROMBIN, INTERFERES, METABOLISM
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Heparins play an important role in cell growth, differentiation, migration and invasion. However, the molecular mechanisms of heparin mediated cellular behaviors are not well defined. To determine the effect of heparin on gene expression, we performed a cDNA microarray in a hepatocellular carcinoma cell line and found that heparin regulates transcription of genes involved in glucose metabolism.