Heparin treatment increases thioredoxin interacting protein expression in hepatocellular carcinoma cells

Gunes A., İŞCAN E., Topel H., Avci S. T., GÜMÜŞTEKİN M., Erdal E., ...More

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol.65, pp.169-181, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 2015
  • Doi Number: 10.1016/j.biocel.2015.05.025
  • Journal Name: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.169-181
  • Keywords: Heparin, HCC, TXNIP, ChoRE, ChoRE associated proteins, CARBOHYDRATE RESPONSE ELEMENT, GLUCOSE, TXNIP, SULFATE, MET, GROWTH, MLX, ANTITHROMBIN, INTERFERES, METABOLISM
  • Dokuz Eylül University Affiliated: Yes

Abstract

Heparins play an important role in cell growth, differentiation, migration and invasion. However, the molecular mechanisms of heparin mediated cellular behaviors are not well defined. To determine the effect of heparin on gene expression, we performed a cDNA microarray in a hepatocellular carcinoma cell line and found that heparin regulates transcription of genes involved in glucose metabolism.