Heparin treatment increases thioredoxin interacting protein expression in hepatocellular carcinoma cells

Gunes, Aysim; İŞCAN, EVİN; Topel, Hande; Avci, Sanem; GÜMÜŞTEKİN, MUKADDES; Erdal, ŞERİFE; Atabey, Nese

doi:10.1016/j.biocel.2015.05.025

Heparin treatment increases thioredoxin interacting protein expression in hepatocellular carcinoma cells

Gunes A., İŞCAN E., Topel H., Avci S. T., GÜMÜŞTEKİN M., Erdal E., ...More

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol.65, pp.169-181, 2015 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 65
Publication Date: 2015
Doi Number: 10.1016/j.biocel.2015.05.025
Journal Name: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.169-181
Keywords: Heparin, HCC, TXNIP, ChoRE, ChoRE associated proteins
Dokuz Eylül University Affiliated: Yes

Abstract

Heparins play an important role in cell growth, differentiation, migration and invasion. However, the molecular mechanisms of heparin mediated cellular behaviors are not well defined. To determine the effect of heparin on gene expression, we performed a cDNA microarray in a hepatocellular carcinoma cell line and found that heparin regulates transcription of genes involved in glucose metabolism.