Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.32, sa.4, ss.302-309, 2004 (Scopus)
In this study, we aimed to compare of effects of remifentanil and fentanyl on hemodynamic parameters and postoperative return of consciousness following the removal of supratentorial space occupying lesions. After Research Ethics' Committee approval and written informed consent from patients, 25 ASA physical status I-III adult patients were randomized into two groups Group I (n=12) received remifentanil 1 μg kg-1 for induction and 0.15 μg kg-1 min-1 for maintenance and Group II (n=13) received fentanyl 2 μg kg-1 for induction and 0.03 μg kg-1 min-1 for maintenance. In both groups intubation was done following vecuronium 0.1 μg mg kg-1 and propofol 2 μg mg kg-1 and anaesthesia was maintained with propofol 50-200 μg kg-1 min-1, O2 40%, N2O 60%. Mean arterial pressure and heart rate were recorded one minute after the basal measurement, entubation intubation, application of skull pins, skin incision, burr hole opening, removal of bone flap, replacement of bone flap, closure of skin and at the end of surgery. The times of to spontaneous breathing, eye opening with verbal command, extubation, modified Aldrete score ≥ 9 and adverse effects were also recorded. The mean arterial pressure at intubation, skin incision, burr hole opening, removal of bone flap, replacement of bone flap, at the end of surgery and the heart rate at skin incision, replacement of bone flap were found to be significantly higher in the fentanyl group when compared with the remifentanil group (p<0.05). The time for reaching modified Aldrete score ≥ 9 was shorter in the remifentanil group when compared to the fentanyl group (p=0.03). We concluded that during craniotomies for the removal of supratentorial space occupying lesions remifentanil can be an alternative to fentanyl, because it provides faster recovery and better control on hemodynamics parameters.